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[11C]PBR28
- Development stage
- Unknown
- Lead developer
- National Institute of Mental Health
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Small Molecules
- Administration
- Intravenous
01
Overview
[11C]PBR28 is a carbon-11 radiolabeled small molecule PET radioligand developed by the National Institute of Mental Health (NIMH). It specifically targets the 18-kDa translocator protein (TSPO), formerly known as the peripheral benzodiazepine receptor (PBR). TSPO is expressed at low levels in the healthy central nervous system but is significantly upregulated in activated microglia and astrocytes during neuroinflammation. [11C]PBR28 was designed as a high-affinity alternative to the first-generation tracer [11C]PK11195, offering improved signal-to-noise ratios and superior specific binding. It is used as a diagnostic imaging tool in clinical research to quantify neuroinflammation across various conditions, including Alzheimer's disease, multiple sclerosis, Parkinson's disease, and traumatic brain injury.
- Other names
- N-acetyl-N-(2-[11C]methoxybenzyl)-2-phenoxy-5-pyridinamine[(11)C] PBR28
02
Targets
TSPO (Translocator Protein (18 kDa))
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